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Marim M. Barghash on Muck Rack

Marim M. Barghash

As seen in: Cell Press
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Articles

Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

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By Mark F. Mabanglo, Keith Wong, Marim M. Barghash, Elisa Leung
| Cell Press Verified
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells to eliminate reactive oxygen species (ROS)-damaged proteins and to sustain oncogenesis. Targeting ClpP to dysregulate its function using small-molecule agonists is a recent strategy in cancer therapy.
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