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Articles by Mario Sims
Admixture-informed polygenic risk reporting using the ePRS framework
Abstract Polygenic risk score values vary with genetic ancestry due to differences in population-specific allele frequencies and linkage disequilibrium patterns. We present a framework to calibrate polygenic risk scores based on ancestral makeup. We propose the “expected polygenic risk score” or ePRS, defined as the expected value of a polygenic risk score based on one’s global or local admixture patterns.
A data harmonization project of 3 large prospective cardiovascular health-focused cohorts
Ayuda Buscar en la ayuda Buscar en la ayuda A data harmonization project of 3 large prospective cardiovascular health-focused cohorts Scarpaci, Matthew M [1] ; Park, Jee Won [2] ; Dionne, Laura [3] ; Needham, Belinda L [4] ; Sims, Mario [5] ; Kanaya, Alka M [6] ; Kandula, Namratha R [7] ; Fava, Joseph L [3] ; Eaton, Charles B [8] ; Howe, Chanelle J [2] ; Dulin, Akilah J [3] [1] Hassenfeld Child Health Innovation Institute, Brown University , Providence, RI , [2] Center for Epidemiologic...
Predicting incident cardiovascular disease among African-American adults: A deep learning approach to evaluate social determinants of health in the Jackson heart study
Loading metrics Open Access Peer-reviewed Research Article Citation: Morris MC, Moradi H, Aslani M, Sims M, Schlundt D, Kouros CD, et al. (2023) Predicting incident cardiovascular disease among African-American adults: A deep learning approach to evaluate social determinants of health in the Jackson heart study. PLoS ONE 18(11): e0294050.
Social Networks and Cardiovascular Disease Events in the Jackson Heart Study
What Is New? Social connectedness is associated with lower risk of coronary heart disease among Black adults, and health behaviors such as smoking may partially explain the association. Control of risk factors such as hypertension and diabetes did not mediate the association between social connectedness and heart disease. What Are the Clinical Implications? Increasing social connections may benefit women's risk of coronary heart disease, stroke, and heart failure.
Relationship between social support and incident hypertension in the Jackson Heart Study: a cohort study
Methods Overview and setting The JHS has been described in detail elsewhere.23 24 Briefly, the study enrolled 5306 African American adults 21 years of age and above from the Jackson, Mississippi metropolitan tricounty area including Hinds, Madison and Rankin counties who completed a baseline examination between 2000 and 2004 (exam 1). There have been two follow-up examinations; the first (examination 2) between 2005– and 2008 and the second (examination 3) between 2009 and 2013.
The role of perceived discrimination in predicting changes in health behaviours among African Americans in the Jackson Heart Study
The role of perceived discrimination in predicting changes in health behaviours among African Americans in the Jackson Heart Study http://orcid.org/0000-0002-3097-0038Allana T. Forde1,2, Mario Sims3, Xu Wang4, Sharrelle Barber2, Ana V.
The role of perceived discrimination in predicting changes in health behaviours among African Americans in the Jackson Heart Study
The role of perceived discrimination in predicting changes in health behaviours among African Americans in the Jackson Heart Study http://orcid.org/0000-0002-3097-0038Allana T. Forde1,2, Mario Sims3, Xu Wang4, Sharrelle Barber2, Ana V.
Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study
Association between goal-striving stress and rapid kidney function decline among African Americans: the Jackson Heart Study http://orcid.org/0000-0003-2255-8067Loretta Cain-Shields1, LáShauntá Glover2, Bessie Young3,4, Mario Sims5 1Department of Data Science, John D.
Importance of Housing and Cardiovascular Health and Well-Being: A Scientific Statement From the American Heart Association
Cardiovascular disease (CVD) disparities are shaped by differences in risk factors across racial/ethnic and socioeconomic groups.
Discrimination and Hypertension Risk Among African Americans in the Jackson Heart Study
Abstract African Americans have a higher risk of hypertension compared with other racial or ethnic groups in the United States. One possible explanation for this disparity is discrimination. Few studies have examined the association between discrimination and incidence of hypertension.
Cardiovascular Health in American Indians and Alaska Natives: A Scientific Statement From the American Heart Association
Abstract BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death among American Indians and Alaska Natives. Over the past 50 years, the prevalence of CVD has been rising among American Indians and Alaska Natives. The objective of this statement is to summarize population-level risk factors and management techniques tailored for the American Indian and Alaska Native populations.
Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study
Introduction Perceiving discriminatory treatment may contribute to systemic inflammation, a risk factor of cardiovascular pathophysiology. This study evaluated the association of self-reported discrimination with changes in high–sensitivity C-reactive protein and the mediating role of adiposity. Methods The sample included 5,145 African-Americans, aged 21–92 years, in the Jackson Heart Study.
Sickle Cell Trait, European Ancestry, and Longitudinal Tracking of HbA1c Among African Americans: The Jackson Heart Study
e-Letters: Observations Studies of differences in glycosylated hemoglobin (HbA1c) have defined race/ethnicity as a social construct (1,2), not using objective biological parameters, and thus comparisons may have been confounded (3). Among blacks without diabetes, we investigated whether the proportion of European genetic ancestry (PEA) mediates the sickle cell trait (SCT) and HbA1c relation and whether PEA tracks HbA1c levels over time accounting for SCT.
Glycemic Markers and Subclinical Cardiovascular Disease: The Jackson Heart Study
CLINICAL PERSPECTIVE We investigated the association of various measures of glucose homeostasis and several indices of subclinical cardiovascular disease, which include measures of cardiac structure/function, coronary artery calcification, carotid intima-media thickness, and peripheral artery disease, in a large sample of blacks in the Jackson Heart Study.
Abdominal Aortic Calcification Among Individuals With and Without Diabetes: The Jackson Heart Study
Diabetes increases mortality by two- to fourfold from atherosclerosis-related causes, including coronary artery disease, stroke, and peripheral artery disease (1). There is a paucity of population-based data on subclinical atherosclerotic disease in arterial beds other than the coronary arteries in persons with diabetes (2).In the Jackson Heart Study (JHS), we examined the association of diabetes with abdominal aortic calcification (AAC) among African Americans.
Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study
Background: Although it is recognized that vitamin D deficiency is associated with cardiovascular disease (CVD) risk factors, and is more common in African Americans (AAs), the pathologic mechanisms by which vitamin D may influence these risk factors are poorly understood.
The Impact of Lifecourse Socioeconomic Position on Cardiovascular Disease Events in African Americans: The Jackson Heart Study
Methods and Results We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large cohort of African Americans. During a median of 7.2‐year follow‐up, 362 new or recurrent CVD events occurred in a sample of 5301 participants aged 21 to 94. Childhood SEP was assessed by using mother's education, parental home ownership, and childhood amenities.
Depressive Symptoms and Risk of Cardiovascular Events in Blacks
Methods and Results—We used data from the Jackson Heart Study to investigate associations of baseline depressive symptoms between 2000 and 2004 with incident stroke and coronary heart disease (CHD) during 10 years.
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