CONFLICT OF INTEREST STATEMENT Paul Muntner is an employee of the US government. The work for this manuscript was conducted prior to assuming this position and does not reflect the views of the US Government. Rohini K Hernandez, Shia T Kent, James E Browning, Keri L Monda, and Brian D Bradbury are employees and shareholder of Amgen Inc. David T Gilbertson has no conflicts to disclose. Kathleen E Hurwitz is employed by and owns equity in Target RWE. Susan S Jick has no conflicts to disclose.