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Marioara Chiritoiu on Muck Rack

Marioara Chiritoiu

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Articles

GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion

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By Nathalie Brouwers, Gabriele Turacchio, Marioara Chiritoiu, Marinella Pirozzi
| Cell Press Verified
Highlights • PERK pathway is required for the production of mIL-1β from proIL-1β • Loss of GRASP55 causes mIL-1β aggregation and affects mIL-1β secretion • IRE1α inhibition causes aggregation of mIL-1β and reduces mIL-1β secretion • GRASP55 controls IRE1α activity in LPS-stimulated macrophages Summary Signal-sequence-lacking interleukin (IL)-1β, is cleaved by caspase-1 to mature mIL-1β, which is secreted, without entering the endoplasmic reticulum.
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