Marisa Edmonds on Muck Rack

Marisa Edmonds

  • Research Technician, UK Dementia Research Institute
London
As seen in: Nature
Research Tech with the Bartels Lab @UCL @UKDRI
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Articles

Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature

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By Sebastiaan De Schepper, James Conway, Matthew Cowley, Annerieke Sierksma, Marisa Edmonds, Daria Gavriouchkina, Mónica Vara-Pérez, Gerard Crowley, Mitchell Bijnen, Kelvin C. Luk, Vuk Cerovic, Menna R. Clatworthy, Zane Jaunmuktane, Kiavash Movahedi, Melanie Greter, Benny Chain, Dario R. Alessi, Soyon Hong, Elizabeth J. Videlock
| Nature Verified
Abstract Emerging evidence suggests that Parkinson’s disease (PD) may have its origin in the enteric nervous system (ENS), from where α-synuclein (αS) pathology spreads to the brain1,2,3,4. Decades before the onset of motor symptoms, patients with PD suffer from constipation and present with circulating T cells responsive to αS, suggesting that peripheral immune responses initiated in the ENS may be involved in the early stages of PD1,5,6,7.
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Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue - Nature Biomedical Engineering

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By Christina E. Toomey, Joseph S. Beckwith, Emma E. Brock, Lisa-Maria Needham, Camille Loiseau, James Evans, Marisa Edmonds, Michele Vendruscolo, Lucien E. Weiss, Sonia Gandhi
| Nature Verified
Abstract Parkinson’s disease (PD) is a neurodegenerative condition characterized by the presence of intraneuronal aggregates containing fibrillar ɑ-synuclein known as Lewy bodies. These large end-stage species are formed by smaller soluble protein nanoscale assemblies, often termed oligomers, which are proposed as early drivers of pathogenesis.
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