CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description jne13445-sup-0001-supinfo.docxWord 2007 document , 17.6 KB Table S1. Rare synonymous variant association testing between IHH and gnomAD cohorts across three MAF bins. REFERENCES 1, , , et al. Rare coding variants in 35 genes associate with circulating lipid levels—a multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022; 109: 81-96. 2, , , et al.