Mark Chiang

Abstract Tumor cells must occupy and thrive in a competitive microenvironment marked by limited metabolites, including essential amino acids like methionine. Using a leukemia suppression model and CRISPR screening, we found that the choline transporter SLC44A1 is overexpressed in leukemia patients and impacts leukemogenesis. Choline is an important nutrient for membrane synthesis and less commonly contributes to the methionine cycle.

Verify Phone Enter the verification code Congrats! Your Phone has been verified Skip to main content Get full access to this article View all available purchase options and get full access to this article. References 1. Freedman SF, Beck AD, Nizam Aet al.Infant Aphakia Treatment Study Group. Glaucoma-related adverse events at 10 years in the Infant Aphakia Treatment Study: A secondary analysis of a randomized clinical trial. JAMA Ophthalmol. 2021;139(2):165–173. 2.

The U.S. Food and Drug Administration (FDA) has granted approval to MSD for an updated indication of its drug Winrevair. The approval allows the use of Winrevair by injection specifically for the treatment of adults diagnosed with pulmonary arterial hypertension (PAH). Pulmonary arterial hypertension is a progressive condition characterized by high blood pressure in the arteries of the lungs, which can lead to heart failure if left untreated.