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Mark Daly

As seen in: Medium, MSN Singapore, National Institutes of Health, Yahoo Entertainment, BBC News, BBC Sport, Bloomberg News, Color Research & Application, Daily Mail, Nature and
External comms for @BAESystemsInc. Writer, skier, skater, mountain biker, strategy gamer, cat friend and sports fan. All views are my own.

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Articles

PGS Browser: a public platform for personalized polygenic score analysis and interpretation

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By Nikita Kolosov, Mary Reeve, Mitja I. Kurki, Vincent Llorens, Timo Sipilä, Adam Herman, Mervi Aavikko, Samuli Ripatti, Aarno Palotie, Mark Daly, Mykyta Artomov, Ivan Molotkov
| Nature Verified
Abstract Polygenic scores (PGSs) quantify individual genetic susceptibility to complex diseases and can identify high-risk individuals well before clinical onset. Their clinical translation, however, requires population-based reference resources, standardized benchmarking, and accessible tools for translating individual scores into disease likelihood.
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Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy

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By Jaakko S. Tyrmi, Juha Karjalainen, Samvida Venkatesh, Clara Benoit-Pilven, Susanna Lemmelä, Søren Brunak, Bitten Aagaard, Mie T Bruun, Christian Erikstrup, Henrik Ullum, Ole B. Pedersen, Karina Banasik, Erik S. Sørensen, Christina Mikkelsen, Michael C Schwinn, Arni Sturluson, Sisse R. Ostrowski, Johannes Kettunen, Henriette Svarre Nielsen, Mette Nyegaard, David Westergaard, Thorunn Rafnar, Patrick Sulem, Kari Stefansson, Priit Palta, Triin Laisk, Taru Tukiainen, Cecilia M Lindgren, Mark Daly, Aki S Havulinna, Hannele Laivuori
| Nature Verified
Abstract Intrahepatic cholestasis of pregnancy, which affects 0.2–2% of pregnancies, is characterized by pruritus, increased aminotransferase activity and elevated serum bile acids. Previous studies have implicated liver-enriched genes in intrahepatic cholestasis of pregnancy.
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Genetic variants affect diurnal glucose levels throughout the day

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By Nasa Sinnott-Armstrong, Satu Strausz, Lea Urpa, Erik Abner, Josephine Johnson, Jesse Valliere, Teele Palumaa, Priit Palta, Hassan S Dashti, Kyong-Mi Chang, Marijana Vujkovic, Mark Daly, Jonathan Pritchard, Richa Saxena, Samuel Jones Verified, Hanna M. Ollila
| Nature Verified
Abstract Circadian rhythms not only coordinate the timing of wake and sleep but also regulate homeostasis within the body, including glucose metabolism. The genetic variants that contribute to the temporal control of glucose levels have not been previously examined.
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