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Articles by Mark Dane
Identification of senescence-associated drivers of tumour growth and progression using a novel microarray platform
Abstract Senescence and the senescence associated secretory phenotype (SASP) are implicated in promoting early tumorigenesis but due to the complexity of SASP it has been difficult to identify the responsible factors. We used canonical SASP factors on our microenvironment microarray (MEMA) platform to systematically identify SASP-associated drivers of tumorigenesis in breast and lung cancer cells.
Oncostatin M orchestrates collective epithelial migration via HIF1A activation
Abstract Extracellular signals strongly influence cell behavior, yet the mechanisms by which specific ligands mediate changes in phenotype remain unclear. The cytokine Oncostatin M (OSM) regulates homeostasis, wound healing, inflammation, and cancer progression. We previously found that OSM induces collective cell migration (CCM), a process whereby cells move as cohesive units while retaining cell-cell contacts, in MCF10A mammary epithelial cells.
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome - Nature Aging
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Abstract Platinum-based chemotherapy is commonly used for non-small cell lung cancer (NSCLC) and high-grade serous ovarian cancer (HGSOC) treatments, yet clinical outcomes remain poor. Cellular senescence and its associated secretory phenotype (SASP) can have multiple tumor-promoting activities, but both are largely unexplored in these cancers.
By David Macías, Jianfeng Ge, Ioana Olan, Jose Martin, Jóse Martin, José Martín Verified, Hui-Ling Ou, Muhamad Hartono, Mary Denholm, Rosalind Kieran, Reuben J. Hoffmann, Mark Dane, Dimitris Veroutis, Guillermo Medrano, Francisca Mulero, Mercedes Jimenez-Linan, Ljiljana Fruk, Carla Martins, Mariano Barbacid, Vassilis G. Gorgoulis, James E. Korkola, Doris Rassl, Gary J Doherty, Robert C Rintoul, Masashi Narita, James Brenton, Daniel Muñoz-Espín, Estela González-Gualda, Samir Morsli, María Pilar Puerto-Camacho
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Nature
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An Altered Extracellular Matrix-Integrin Interface Contributes to Huntington’s Disease-Associated CNS Dysfunction in Glial and Vascular Cells
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Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects - Nature Communications
Abstract Identifying effective therapeutic treatment strategies is a major challenge to improving outcomes for patients with breast cancer. To gain a comprehensive understanding of how clinically relevant anti-cancer agents modulate cell cycle progression, here we use genetically engineered breast cancer cell lines to track drug-induced changes in cell number and cell cycle phase to reveal drug-specific cell cycle effects that vary across time.
Systematic Replication Enables Normalization of High-throughput Imaging Assays
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Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments
Convergence and Technologies Gregory J. Kimmel, Mark Dane, Laura M. Heiser, Philipp M. Altrock and Noemi Andor DOI: 10.1158/0008-5472.CAN-20-1231 Published November 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Breast cancer progresses in a multistep process from primary tumor growth and stroma invasion to metastasis.
Integrating mathematical modeling with high throughput imaging explains how polyploid populations behave in nutrient-sparse environments
Research Article Gregory J. Kimmel, Mark Dane, Laura M. Heiser, Philipp M. Altrock and Noemi Andor DOI: 10.1158/0008-5472.CAN-20-1231 Abstract Breast cancer progresses in a multistep process from primary tumor growth and stroma invasion to metastasis. Nutrient-limiting environments promote chemotaxis with aggressive morphologies characteristic of invasion.
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
Subtype Intrinsic Responses to NRG1β and HGF Are Observed in 3D Cultures and Murine Xenografts Pertuzumab and Lapatinib Combinations in L-HER2+ Cells Treated with NRG1β Our initial studies used MEMAs (Lin et al., 2012xFabrication and use of microenvironment microarrays (MEArrays). Lin, C.H., Lee, J.K., and LaBarge, M.A. J. Vis. Exp.
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