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Mariano Barbacid on Muck Rack

Mariano Barbacid

As seen in: El País, Nature, Wiley Online Library, The Conversation, Antena 3, Medical Xpress, Cell Press, El Comercio, Molecular Cancer Research
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Articles

A disease model resource reveals core principles of tissue-specific cancer evolution

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By Sebastian P. Mueller, Markus Tschurtschenthaler, Miguel Silva, Riccardo Trozzo, Thorsten Kaltenbacher, Magdalena Zukowska, Daniele Lucarelli, Rupert Öllinger, Nina Lucia Groß, Tanja Groll, Jeroen M. Bugter, Stefanie Barthel, Chiara Falcomatà, Alexander Strong, Aristeidis Papargyriou, Roman Maresch, David Sailer, Christian Schneeweis, Lisa Frohlich, Christine Klement, Juan Montero Verified, Ute Jungwirth, Maximilian Reichert, Markus Moser, Jens Neumann, George S. Vassiliou, Juan Enrique Cadiñanos, Ignacio Varela Verified, Carsten Marr, Daniel F. Alonso, Pier-Luigi Lollini, Jean J. Zhao, Louis Chesler, Clare M. Isacke, Angela Riedel, Christian J. Braun, Martin L. Sos, Filippo Beleggia, Hans Reinhardt, Monica Musteanu, Mariano Barbacid, Michael Quante, Marc Schmidt-Supprian, Günter Schneider, Simon Clare, Trevor D. Lawley, Gordon Dougan, Katja Steiger, Nathalie Conte, Allan Bradley, Dieter Saur, Roland Rad, Niklas de Andrade Krätzig, Chiara Thordsen, Perrine Simon, Frederic Saab, Joscha Griger, Jessica Löprich, Antonio E. Zaurito, Linus R. Schömig, Cordelia Brandt, Mulham Najajreh, Katharina A. N. Collins, Sebastian Burger, Alexander Belka, Lena Rad
| Nature Verified
Abstract Oncogenes such as KRAS display marked tissue specificity in their oncogenic potential, genetic interactions and phenotypic effects, but the underlying determinants remain largely unresolved1,2,3,4,5. Here, to address these questions, we developed the Mouse Cancer Cell line Atlas, a broad-utility resource of 590 comprehensively characterized models across a wide range of entities (www.mcca.tum.de).
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Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome - Nature Aging

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By David Macías, Jianfeng Ge, Ioana Olan, Jose Martin, Jóse Martin, José Martín Verified, Hui-Ling Ou, Muhamad Hartono, Mary Denholm, Rosalind Kieran, Reuben J. Hoffmann, Mark Dane, Dimitris Veroutis, Guillermo Medrano, Francisca Mulero, Mercedes Jimenez-Linan, Ljiljana Fruk, Carla Martins, Mariano Barbacid, Vassilis G. Gorgoulis, James E. Korkola, Doris Rassl, Gary J Doherty, Robert C Rintoul, Masashi Narita, James Brenton, Daniel Muñoz-Espín, Estela González-Gualda, Samir Morsli, María Pilar Puerto-Camacho
| Nature Verified
Abstract Platinum-based chemotherapy is commonly used for non-small cell lung cancer (NSCLC) and high-grade serous ovarian cancer (HGSOC) treatments, yet clinical outcomes remain poor. Cellular senescence and its associated secretory phenotype (SASP) can have multiple tumor-promoting activities, but both are largely unexplored in these cancers.
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The rapidly growing landscape of RAS inhibitors: from selective allele blockade to broad inhibition strategies

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By Matthias Drosten, Mariano Barbacid
| Wiley Online Library Verified
FDA U.S. Food and Drug Administration GAP GTPase-activating protein GDP guanosine diphosphate GTP guanosine triphosphate MAPK mitogen-activated protein kinase NMPA National Medical Products Administration PI3K phosphatidyl inositol 3-kinase RAS proteins are small GTPases that cycle between an inactive, GDP-bound (OFF) state and an active, GTP-bound (ON) state, in which they transmit signals from extracellular receptors to promote cell proliferation or block apoptosis, among other functions.
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