Decision science, Family Guy, and why the “safe” choice is often the riskiest. Mark Shrime, MD, PhD · Follow 8 min read · -- I know exactly when I ruined my life. A touch overdramatic, yeah, but stick with me, because this story — about a single moment in Singapore 27 years ago — might also explain why you’re stuck in a job you hate, why you’re still living in a city that doesn’t set your soul on fire, or why you haven’t started that business or written that book or launched that podcast.