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Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder with overlapping myelodysplastic (MD) and myeloproliferative (MP) features [1, 2]. Somatic TET2 mutations (TET2MT) are present in 40–60% of CMML patients and are associated with improved overall (OS) and acute leukemia free survival (LFS) [3, 4]. This is due, in part, to a protective effect of TET2MT in the context of adverse ASXL1MT and a higher response rate to hypomethylating agents (HMA) [4, 5].
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