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Articles by Mark Ladinsky
Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues
Abstract HIV-1 delivers its genetic material to infect a cell after fusion of the viral and host cell membranes, which happens after the viral envelope (Env) binds host receptor and co-receptor. Binding host receptor CD4 to Env results in conformational changes that allow interaction with a co-receptor (CCR5 or CXCR4).
The genomic and cellular basis of biosynthetic innovation in rove beetles
Tempo and Mode in Evolution. Columbia University Press, 1944 A conceptual framework of evolutionary novelty and innovation. Biol. Rev. 2021; 96: 1-15https://doi.org/10.1111/brv.12643 Species Inventory. in: Groombridge B. Global Biodiversity. Spinger, 1992: 17-39https://doi.org/10.1007/978-94-011-2282-5_4 Order Coleoptera Linnaeus, 1758. In: Animal biodiversity: An outline of higher-level classification and survey of taxonomic richness. Zootaxa.
9-fold symmetry is not essential for centriole elongation and formation of new centriole-like structures - Nature Communications
Abstract As daughter centrioles assemble during G2, they recruit conserved Ana3/RTTN followed by its partner Rcd4/PPP1R35. Together, this contributes to the subsequent recruitment of Ana1/CEP295, required for the centriole’s conversion to a centrosome. Here, we show that Rcd4/PPP1R35 is also required to maintain 9-fold centriole symmetry in the Drosophila male germline; its absence causes microtubule triplets to disperse into a reduced number of doublet or singlet microtubules.
An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo
Cellular growth is the result of passive physical constraints and active biological processes. Their interplay leads to the appearance of robust and ubiquitous scaling laws relating linearly cell size, dry mass, and nuclear size. Despite accumulating experimental evidence, their origin is still unclear. Here, we show that these laws can be explained quantitatively by a single model of size regulation based on three simple, yet generic, physical constraints defining altogether the Pump-Leak model.
The genomic and cellular basis of biosynthetic innovation in rove beetles
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Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis
Segmented filamentous bacteria (SFB) are anaerobic, spore-forming, clostridia-like organisms that are important immune modulators in the mammalian gut. For some reason, SFB do not provoke inflammatory responses. Ladinsky et al. probed the mechanistic basis of this soothing effect in mice. SFB attach tightly to intestinal epithelial cells via a hook-like structure. Bacterial material is extruded from the hook and enters the host cell by endocytosis.
Nanoscale-length control of the flagellar driveshaft requires hitting the tethered outer membrane
The bacterial flagellum is important in bacterial pathogenesis and biofilm formation. It is a rotary nanomotor that allows bacteria to propel themselves through liquids and across surfaces. Researchers interested in nanoscale robotics use the bacterial flagellum as a model for a machine that self-assembles on the nanoscale. Cohen et al. examined exactly how the flagellum precisely measures its shaft so that it spans, but does not extend beyond the edge of, the periplasm.
When beneficial bacteria knock but no one is home
The community of beneficial bacteria that live in our intestines, known as the gut microbiome, are important for the development and function of the immune system. There has been growing evidence that certain probiotics--therapies that introduce beneficial bacteria into the gut--may help alleviate some of the symptoms of intestinal disorders such as Crohn's disease.
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