Mark Li on Muck Rack

Mark Li

Hong Kong
As seen in: Medium, PLOS Biology, MDPI, San Francisco Business Times, Science Magazine, Cell Metabolism, Cell Press, Dove Medical Press, Lexology, Vogue Business and
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Articles

Mitochondrial control of glycerolipid synthesis by a PEP shuttle

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By Tadashi Yamamuro, Daisuke Katoh, Guilherme Martins Silva, Hiroshi Nishida, Satoshi Oikawa, Yusuke Higuchi, Dandan Wang, Masanori Fujimoto, Naofumi Yoshida, Mark Li, Jihoon Shin, Zezhou Zhao, Jin-Seon Yook, Lijun Sun, Shingo Kajimura
| Cell Press
Keywords bioenergetics mitochondria glyceroneogenesis obesity hepatic steatosis diabetes Get full text access Log in, subscribe or purchase for full access. References 1. Chakrabarty, R.P. ∙ Chandel, N.S. Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate Cell Stem Cell. 2021; 28:394-408 2. Granath-Panelo, M. ∙ Kajimura, S. Mitochondrial heterogeneity and adaptations to cellular needs Nat. Cell Biol. 2024; 26:674-686 3. Yu, S. ∙ Meng, S. ∙ Xiang, M. ...
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Mitochondrial control of fuel switching via carnitine biosynthesis

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By S. M. Frolov, Shany Dror, Christopher Heins, Christopher Auger, Hiroshi Nishida, Bo Yuan, Masanori Fujimoto, Mark Li, Daisuke Katoh, Dandan Wang, Melia Granath-Panelo, Jihoon Shin, Jin-Seon Yook, Alexander S. Banks, Sheng Hui, Lijun Sun, Guilherme Martins Silva, Rose Witte
| Science Magazine
Abstract Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthesis from trimethyllysine (TML) is essential, particularly for those who consume plant-based diets; however, its molecular regulation and physiological role remain elusive. Here, we identify SLC25A45 as a mitochondrial TML carrier that controls carnitine biosynthesis and fuel switching.
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Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue

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By Christopher Auger, Mark Li, Masanori Fujimoto, Kenji Ikeda, Jin-Seon Yook, Timothy O’Leary, Satoshi Oikawa, Anthony R.P. Verkerke, Kosaku Shinoda, PATRICK GRIFFIN, Kenji Inaba, Roland H. Stimson, Shingo Kajimura, Cai Xiaohan, Patrick Griffin, Cai Xiaohan, Shingo Kaji
| Cell Metabolism
Keywords thermogenesis UCP1-independent Ca2+ cycling energy balance obesity Introduction The principle of thermogenesis follows Joule’s first law: Q (J) = I2 × R × T, where I is current, R is resistance, and T is time.1 This formula explains how proton uncoupling of the mitochondrial electron transport chain (ETC) by uncoupling protein 1 (UCP1) leads to thermogenesis in brown and beige adipocytes.
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