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Articles by Mark Nitz
OC43 clinical isolate spike proteins have distinct carbohydrate-binding properties
Abstract The human coronavirus HCoV-OC43 (OC43) is the most widespread of the four common cold-causing seasonal coronaviruses, and tissue culture-adapted strains of it have been used for ~50 years. Nevertheless, clinical isolates of OC43 differ from tissue culture-adapted OC43 in ways that call into question the value of the latter as a model. Among these are differences in their entry mechanisms and the activities of their hemagglutinin-esterases (HE).
Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes - Nature Communications
Abstract The human coronavirus HKU1 uses both sialoglycoconjugates and the protein transmembrane serine protease 2 (TMPRSS2) as receptors. Carbohydrate binding leads to the spike protein up conformation required for TMPRSS2 binding, an outcome suggesting a distinct mechanism for driving fusion of the viral and host cell membranes.
Exploration of Glycosyl Dithioimidocarbonates in Photoinduced Desulfurative Cross-Coupling Reactions
Organic Letters Cite this: Org. Lett. 2024, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Exploration of Glycosyl Dithioimidocarbonates in Photoinduced Desulfurative Cross-Coupling Reactions
Methods for analyzing tellurium imaging mass cytometry data
Loading metrics Open Access Peer-reviewed Research Article Jay Bassan , Mark Nitz Jay Bassan, Mark Nitz Published: September 3, 2019 https://doi.org/10.1371/journal.pone.0221714 Figures Abstract Imaging mass cytometry (IMC) is a technique allowing visualization and quantification of over 40 biological parameters in a single experiment with subcellular spatial resolution, however most IMC experiments are limited to endpoint analysis with antibodies and DNA stains.
DNA directed damage using a brominated DAPI derivative
DNA directed damage using a brominated DAPI derivative Photodynamic therapy (PDT) is a clinically approved cancer treatment that uses light, oxygen and a photosen-sitizer to produce localized reactive oxygen species (ROS). Due to the short lifetime of ROS, the location of the photosensitizer in the cell is believed to be key de-terminant governing the outcome of PDT.
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