Tarini Gunawardena on Muck Rack

Tarini Gunawardena

As seen in: Nature
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Articles

OC43 clinical isolate spike proteins have distinct carbohydrate-binding properties

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By Min Jin, Ying Liu, Zhijie Li, Alan Wong , Marc Desforges, Adam Forman, Mark Nitz, Theo J Moraes, Masahiro Narimatsu, Jeffrey L. Wrana, Hai Yu, Xi Chen, Zaky Hassan, Tarini Gunawardena, James M. Rini
| Nature
Abstract The human coronavirus HCoV-OC43 (OC43) is the most widespread of the four common cold-causing seasonal coronaviruses, and tissue culture-adapted strains of it have been used for ~50 years. Nevertheless, clinical isolates of OC43 differ from tissue culture-adapted OC43 in ways that call into question the value of the latter as a model. Among these are differences in their entry mechanisms and the activities of their hemagglutinin-esterases (HE).
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