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Articles by Markus Aly
MRI-Targeted or Standard Biopsy in Prostate Cancer Screening
Article Figures/Media Metrics Related Articles Abstract Background High rates of overdiagnosis are a critical barrier to organized prostate cancer screening. Magnetic resonance imaging (MRI) with targeted biopsy has shown the potential to address this challenge, but the implications of its use in the context of organized prostate cancer screening are unknown.
90‐day cause‐specific mortality after radical prostatectomy. Nationwide population‐based study
ORIGINAL ARTICLE Johan Björklund, Corresponding Author johan.bjorklund@ki.se orcid.org/0000-0003-3254-3993 The Institution for Molecular Medicine and Surgery, Urology, Karolinska Institutet, Stockholm, Sweden Department of Pelvic cancer, Karolinska University Hospital, Stockholm, Sweden Corresponding Author: Johan Bjorklund.
Are Prostate Specific-Antigen (PSA) and age associated with the risk of ISUP Grade 1 prostate cancer? Results from 72 996 individual biopsy cores in 6 083 men from the Stockholm3 study
Loading metrics Open Access Peer-reviewed Research Article Thorgerdur Palsdottir , Tobias Nordström, Markus Aly, Johan Lindberg, Mark Clements, Lars Egevad, Henrik Grönberg, Martin Eklund Thorgerdur Palsdottir, Tobias Nordström, Markus Aly, Johan Lindberg, Mark Clements, Lars Egevad, Henrik Grönberg, Martin Eklund Published: June 13, 2019 https://doi.org/10.1371/journal.pone.0218280 Figures Abstract Background Knowledge about the relationship between PSA, age and ISUP grade group (ISUP) 1...
Objectively measured mobilisation is enhanced by a new behaviour support tool in patients undergoing abdominal cancer surgery
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 The Activity board (Ming-It, Sweden) Fig. 2 Mobilisation variables, presented for each day, median (95 % CI) for the first three postoperative days. Including the patients who had accelerometer at least 12 hours all of the three first days (n = 118). Abstract Introduction Mobilisation reduces the risk of complications after abdominal surgery.
Prostate Cancer Diagnostics Using a Combination of the Stockholm3 Blood Test and Multiparametric Magnetic Resonance Imaging
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig. 1 Diagnostic strategies for the detection of prostate cancer assessed in STHLM3 MRI. bx. = biopsy; MRI = magnetic resonance imaging; STHLM3 = Stockholm3. Fig. 2 Number of detected prostate cancers and performed biopsies by diagnostic strategy in 532 men coming for prostate cancer workup in clinical practice. bx.
Time-to-event Outcomes in Men with Nonmetastatic Castrate-resistant Prostate Cancer-A Systematic Literature Review and Pooling of Individual Participant Data - European Urology Focus
Figure 1Figure 1 shows pooled KM curves for different time-to-event outcomes in placebo arms of RCTs. Individual studies and corresponding digitized KM curves per outcome are presented in the Supplementary material.Fig.
The Stockholm-3 Model for Prostate Cancer Detection: Algorithm Update, Biomarker Contribution, and Reflex Test Potential
After removing intact PSA and including the HOXB13 SNP in the set of predictors, and fitting the S3M to more data, we estimated an AUC of 0.75 (95% CI 0.73–0.77) for predicting GS ≥7 prostate cancers, which is a slight improvement compared to the result reported by Grönberg et al (AUC 0.74, 95% CI 0.72–0.75). From Table 2, Table 4 it is evident that the collection of predictors together is beneficial for reducing unnecessary biopsies.
Balancing Overdiagnosis and Early Detection of Prostate Cancer using the Stockholm-3 Model
The S3M (Stockholm-3 Model) test improves discrimination for high-grade (Gleason score ? 7) prostate cancer compared with prostate-specific antigen (PSA) testing. Published results from the Stockholm-3 study represent a snapshot of possible outcomes for prostate cancer detection using the S3M test. In this brief report, we show how the full range of cancer detection rates and percent saved biopsies depend on the chosen S3M cut-off for recommending prostate biopsy.
The Stockholm-3 (STHLM3) Model can Improve Prostate Cancer Diagnostics in Men Aged 50-69 yr Compared with Current Prostate Cancer Testing
Prostate cancer screening is associated with low specificity, unnecessary biopsies, and overdiagnosis. We have previously shown that the Stockholm-3 model (S3M) can reduce biopsies compared with using prostate-specific antigen (PSA) ?3?ng/ml as an indication for biopsy.
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