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Markus Barden on Muck Rack

Markus Barden

As seen in: Nature, MDPI, The BMJ, BioRxiv
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Articles

Drug-controlled CAR T cells through the regulation of cell–cell interactions - Nature Chemical Biology

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By Leo Scheller, Rocío Castellanos-Rueda, Markus Barden, Melanie Triboulet, Morteza Hafezi, Sarah Ash, Sailan Shui, Elisabetta Cribioli, Patrick Reichenbach, Jimmy Maillard, Anthony Marchand, Sandrine Georgeon, Benita Wolf, Hinrich Abken, Bruno E. Correia, Melita B. Irving, Raphaël B. Di Roberto
| Nature Verified
Abstract Chimeric antigen receptor (CAR) T cell therapy is constrained by on-target, off-tumor toxicities and cellular exhaustion because of chronic antigen exposure. CARs incorporating small-molecule controlled on- and off-switches can enhance both safety and therapeutic efficacy but their design is limited by the scarcity of nonimmunogenic protein elements responsive to nonimmunosuppressive, clinically approved drugs with favorable pharmacodynamics.
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Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function

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By Markus Barden, Moritz Ertelt, Patrick Ronan Elsenbroich, Vivian Haas
| The BMJ Verified
Methods The structure of all scFvs was predicted with AlphaFold2.18 The solution builder of CHARMM‐GUI19 was used for system solvation with TIP3P water molecules, and charge was neutralized with NaCl. All simulations used the Amber ff19sb force field.20 The calculations were performed with the Amber molecular dynamics (MDs) package through the pmemd software.21 After an initial minimization step, Langevin dynamics with a friction coefficient of 1 ps−1 were applied for linear heating of the...
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Development of antigen-dextramers for detection and evaluation of CAR T cells

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By Rasmus Friis, Cecilie Schiøth Krüger-Jensen, Markus Barden, Maria Ormhoej
| BioRxiv
Abstract Background: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape of hematologic cancers by engineering T cells to specifically target and destroy cancer cells. Monitoring CAR T cell activity and function is essential for optimizing therapeutic outcomes, but existing tools for CAR detection are often limited in specificity and functional assessment capability.
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