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Articles by Markus Elsner
A deep-learning framework reveals whole-body perturbations at cell level
Abstract Many diseases, including obesity, have systemic effects that perturb multiple organ systems throughout the body1,2. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lacking. Here we developed MouseMapper, a suite of foundation-model-based deep-learning algorithms enabling multi-system analysis of disease across the entire mouse body.
Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - Nature Biotechnology
Abstract Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision Nanocarrier Identification (SCP-Nano), an integrated experimental and deep learning pipeline to comprehensively quantify the targeting of nanocarriers throughout the whole mouse body at single-cell resolution.
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
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Keywords SARS-CoV-2 spike protein skull brain long COVID meninges mRNA vaccine neuroinflammation neurodegeneration tissue clearing Introduction SARS-CoV-2 infection is associated with numerous neurological complications1,2,3 and a heightened risk of ischemic strokes.4,5 Even mild cases of COVID-19 can result in long-term effects, including brain fogging and reduced gray matter thickness.6,7,8 While some studies detected SARS-CoV-2 in brain tissue,3,9,10,11,12 others did not,12,13,14,15,16...
By Zhouyi Rong, Hongcheng Mai, Gregor Ebert, Saketh Kapoor, Victor G. Puelles, Jan Czogalla, Danilo Prtvar, Inderjeet Singh, Julia Schädler, Claire Delbridge, Hanno Steinke, Katja Schmidt, Christian J. Braun, Viktoria Ruf, Mayar Ali, Kurt-Wolfram Sühs, Mojtaba Nemati, Franziska Hopfner, Fatma Tritar Cherif, Zeynep Ilgin Kolabas, Muge MOLBAY, Izabela Horvath, Natalie Krahmer, Ali Önder Yildirim, Siegfried Ussar, Jochen Herms, Tobias B. Huber, Sabina Tahirovic, Nikolaus Plesnila, Gunter Hoglinger, Benjamin Ondruschka, Ingo Bechmann, Ulrike Protzer, Markus Elsner, Harsharan Singh Bhatia, Farida Hellal, Ali Erturk, Senbin Hu, Jinpeng Su, Hannah Frenzel, Gina Bruch, Selin Ulukaya, Denise Jeridi, Daniele Mistretta, Özüm Sehnaz Caliskan, Jochen Martin Wettengel, Susanne M. Schwarzmaier
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Cell Host & Microbe
Verified
Whole-body cellular mapping in mouse using standard IgG antibodies - Nature Biotechnology
Abstract Whole-body imaging techniques play a vital role in exploring the interplay of physiological systems in maintaining health and driving disease. We introduce wildDISCO, a new approach for whole-body immunolabeling, optical clearing and imaging in mice, circumventing the need for transgenic reporter animals or nanobody labeling and so overcoming existing technical limitations.
Mouse development hits the big screen
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p53 thwarts the editors
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Mosaic mice ace functional genomics
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Erratum: Stabilizing prospects for a universal flu vaccine
In the version of this article initially published, the name and title of the author, Markus Elsner, Senior Editor, was omitted. The error has been corrected in the HTML and PDF versions of the article.
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