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Sena Gül Turhan

As seen in: Nature, Cell Press
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Articles

Physiological brain clearance architecture revealed by neuronal protein tracing

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By Yuichi Chayama, Nalini Rao, Daniela Perla, Zimo Zhang, Madigan Reid, Sophia Nelson, Xinlan Wen, Bella Ding, Jessica Blumenfeld, Amanda Apolonio, Sahith Doddipalli, Haoyue Zhou, Sena Gül Turhan, Pu-Yun Shih, Matthias Brendel, Ying-Hui Fu, Ali Erturk, Zeynep Ilgin Kolabas, Yadong Huang, Andrew Yang
| Cell Press Verified
Keywords brain waste clearance brain borders CNS drainage cerebrospinal fluid neuroimmunology Alzheimer’s disease dura skull immune tolerance Introduction The brain’s high metabolic activity produces waste that must be continuously cleared to maintain neural function and homeostasis.1,2,3 In the absence of a conventional lymphatic system, the central nervous system (CNS) relies on a complex network involving cerebrospinal fluid (CSF), perivascular spaces, and meningeal pathways to manage...
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A deep-learning framework reveals whole-body perturbations at cell level

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By Doris Kaltenecker, Izabela Horvath, Rami Al-Maskari, Ying Chen, Zeynep Ilgin Kolabas, Luciano Hoeher, Mihail Ivilinov Todorov, Saketh Kapoor, Louis B Kuemmerle, Hanno Steinke, Mayar Ali, Florian Kofler, Pauline Morigny, Julia Geppert, Denise Jeridi, Bastian Wittmann, Jie Luo, Suprosanna Shit, Melissa Ertürk, Laurent Simons, Chenchen Pan, Marie Piraud, Daniel Rueckert, Maria Rohm, Farida Hellal, Markus Elsner, Harsharan Singh Bhatia, Ingo Bechmann, Bjoern Menze, Stephan Herzig, Johannes Christian Paetzold, Mauricio Berriel Diaz, Ali Erturk, David-Paul Minde, Sena Gül Turhan, Tim Wohlgemuth, Carolina Cigankova, Victor Miro Kolenic, Nilsu Gür, Eren Aydeniz, Alara Yücecan
| Nature Verified
Abstract Many diseases, including obesity, have systemic effects that perturb multiple organ systems throughout the body1,2. However, tools for comprehensive, high-resolution analysis of disease-associated changes at the whole-body scale have been lacking. Here we developed MouseMapper, a suite of foundation-model-based deep-learning algorithms enabling multi-system analysis of disease across the entire mouse body.
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