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Marlène Lac on Muck Rack

Marlène Lac

As seen in: Nature, Science Magazine
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Articles

Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity

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By Deborah Carper, Hyun Lee Verified, Nolan Tucker, Marlène Lac
| Science Magazine Verified
Abstract Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels and a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle and adipose tissue. However, no study has so far provided evidence for a causal link between atrial NP (ANP)/GCA deficiency and T2D pathogenesis. Here, we show that both systemic and skeletal muscle ANP/GCA deficiencies in mice promote metabolic disturbances and prediabetes.
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Common mouse models of chronic kidney disease are not associated with cachexia - Communications Biology

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By Nathalie Viguerie, Claire Laurens, Marlène Lac, Laurent Monbrun
| Nature Verified
Abstract The 5/6 nephrectomy and adenine-induced nephropathy mouse models have been extensively used to study Chronic Kidney Disease (CKD)-related cachexia. One common caveat of these CKD models is the cross-sectional nature of comparisons made versus controls. We here performed a comprehensive longitudinal assessment of body composition and energy metabolism in both models.
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