Marta Rúbies Bedós on Muck Rack

Marta Rúbies Bedós

As seen in: Nature, The Journal of Clinical Investigation
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Articles

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer - Nature Communications

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By Ginte Kutkaite, Marta Rúbies Bedós, Michael P. Menden
| Nature Verified
Abstract Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leverage genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Culture System focusing on triple-negative breast cancer (TNBC). We reveal that NEDD8 loss in cancer cells causes a vulnerability to nivolumab (anti-PD-1).
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Interleukin-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy

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By Divya Bharathi Nagarajan, Gürcan Tunalı, Marta Rúbies Bedós, Patrik Fridh
| The Journal of Clinical Investigation
ResearchIn-Press PreviewImmunologyOncology Open Access | 10.1172/JCI161084 J Clin Invest. https://doi.org/10.1172/JCI161084. Copyright © 2023, Tunalı et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Inflammatory mediators released by cancer cells promote the induction of immune suppression and tolerance in myeloid cells.
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