Martha Trevino on Muck Rack

Martha Trevino

Monterrey
As seen in: El Norte, JNeurosci
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Articles

A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of Scn1b

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By Fernando Guillen Verified, Martha Trevino, Audrey Brumback
| JNeurosci Verified
A Novel Mouse Model for Developmental and Epileptic Encephalopathy by Purkinje Cell-Specific Deletion of Scn1b Fernando Isaac Guillén, Mendee A. Geist, Shao-Ying Cheng, Arwen M. Harris, Martha E. Treviño, Hiroshi Nishiyama, Audrey C. Brumback, MacKenzie A. Howard Journal of Neuroscience 10 December 2025, 45 (50) e2184242025; DOI: 10.1523/JNEUROSCI.2184-24.2025
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A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of Scn1b

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By F. Isaac Guillen, Martha Trevino, Audrey Brumback
| JNeurosci Verified
Abstract Loss of function variants of SCN1B are associated with a range of developmental and epileptic encephalopathies (DEEs), including Dravet syndrome. These DEEs feature a wide range of severe neurological disabilities, including changes to social, motor, mood, sleep, and cognitive function which are notoriously difficult to treat, and high rates of early mortality.
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