Understanding Hypertrophic Cardiomyopathy: From Disease Mechanisms to Clinical Management - Episode 7 Published on: , , , MAPLE HCM reveals aficamten beats beta blockers in obstructive HCM, reshaping first-line therapy debates amid insurance hurdles. This episode, titled Insights from the MAPLE Trial: Clinical Implications for oHCM Management, features panelists discussing the following question: Can you please discuss the MAPLE trial and its clinical implications? Led by Dr. Maron, Drs.