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Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment

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By Laura Remesal, Juliana Sucharov-Costa, Yuting Wu, Karishma Pratt, Gregor Bieri, Amber R. Philp, MASON PHAN, Turan Aghayev, Charles W. III, Elizabeth G. Wheatley, Bende Zou, Brandon R. Desousa, Julien Couthouis, Isha H. Jian, Xinmin Xie, Yi Lu, Jason Maynard, Alma L. Burlingame, Saul A. Villeda
| Nature Verified
Abstract Understanding cellular and molecular drivers of age-related cognitive decline is necessary to identify targets to restore cognition at old age. Here we identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that impairs cognition. Using transcriptomic and mass spectrometry approaches, we detect an increase in neuronal FTL1 in the hippocampus of aged mice, the levels of which correlate with cognitive decline.
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