Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Mathieu Dubé
Beaver dam failures: Reconciling science, perception and policy for sustainable river management in Quebec (Canada)
1 INTRODUCTION Beavers (Castor fiber, Castor canadensis) are well known to heavily influence river corridor hydrology through dam construction (Larsen, Larsen, & Lane, 2021; Stoll & Westbrook, 2020). They are important geomorphic agents affecting mainly first- and second-order streams, often described as “ecosystem engineers” (Brazier et al., 2021; Butler, 1995; Gurnell, 1998; Larsen, Larsen, & Lane, 2021; Westbrook, Cooper, & Butler, 2013; Wohl, 2021).
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells
Highlights • Spontaneously active HIV RNA+ and protein+/− reservoirs exist in people with HIV on ART • These are enriched in central memory and CCR6- and activation-marker-expressing cells • Proviruses integrated in these active reservoir cells are mostly defective • Spontaneously active reservoirs correlate with HIV-specific CD4+ and CD8+ T cells Summary Spontaneous transcription and translation of HIV can persist during suppressive antiretroviral therapy (ART).
A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile.
Cellular immune defects associated with suboptimal responses to SARS-CoV-2 mRNA vaccination in people receiving hemodialysis (HD) are poorly understood. We longitudinally analyze antibody, B cell, CD4+, and CD8+ T cell vaccine responses in 27 HD patients and 26 low-risk control individuals (CI). The first two doses elicit weaker B cell and CD8+ T cell responses in HD than in CI, while CD4+ T cell responses are quantitatively similar.
Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function
Summary Background Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown. Methods We examined immune checkpoint (IC) expression and function in HIV-specific CD4+ T cells of viremic individuals (≥5000 vRNA cp/ml, n = 17) prior to ART and persons with spontaneous (n = 11) or therapy-induced (n = 16) viral suppression (<40 cp/ml).
Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity
Highlights • Expression of p24 protein in induced vRNA+ cells is rare during ART suppression • LRAs induce class-specific viral gene transcription and translation patterns • Induced transcriptionally active proviruses are mostly defective, even in p24+ cells • Identical HIV-1 clones can adopt diverse transcriptional and translational states Summary Although understanding the diversity of HIV-1 reservoirs is key to achieving a cure, their study at the single-cell level in primary samples...
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Mathieu
Contact Mathieu, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack