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Matous Palek

As seen in: BioRxiv
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Articles

An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks

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By Yiting Cao, Yingzheng Wang, Jumana Badar, Matous Palek
| BioRxiv
Abstract In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synthesis that protects genomic integrity. Little is understood about the regulatory mechanisms of replication stress recovery, including the mechanisms involved in the restart of stalled replication forks.
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