Yingzheng Wang

Abstract In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synthesis that protects genomic integrity. Little is understood about the regulatory mechanisms of replication stress recovery, including the mechanisms involved in the restart of stalled replication forks.

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2. Results and Discussion 2.1. Characterisation of iRGD-LP-CUR-PIP The preparation of iRGD-LP-CUR-PIP is shown in Figure 1A. The average grain diameter of iRGD-LP-CUR-PIP was about 93 nm ± 0.9 nm and the PDI was 0.2 ± 0.015. The zeta potential of iRGD-LP-CUR-PIP is shown in Table 1. The entrapment efficiency of iRGD-LP-CUR-PIP indicated that CUR and PIP were almost trapped within the liposomes. The typical particle size and distribution of iRGD-LS-CUR-PIP are shown in Figure 1B.