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Matthew Aaron Loberg on Muck Rack

Matthew Aaron Loberg

As seen in: BioRxiv
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Articles

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations

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By George J. Xu, Sheau-Chiann Chen, Hua-Chang Chen, Matthew Aaron Loberg
| BioRxiv
Abstract Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic thyroid carcinoma is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an integrated thyroid cancer single-cell sequencing atlas with spatial transcriptomics and bulk RNA-sequencing, we define stromal cell subpopulations and tumor-stromal cross-talk occurring across the histologic and mutational spectrum of thyroid cancer.
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