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Abstract Introduction: Macrophages are highly plastic innate immune cells that have a broad range of phenotypic and functional roles in the body. The Wnt/β-catenin signaling pathway is known to play important roles in regulating the immune system, but the literature contains contradictory evidence for how Wnt impacts macrophages.
1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA 2Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston TX 77030 3Department of Pediatrics, Division of Medical Genetics and Genomic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA 4School of Psychology, University of Houston, Houston, TX, USA 5Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA 6Department of Pediatrics,...
Abstract Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic thyroid carcinoma is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an integrated thyroid cancer single-cell sequencing atlas with spatial transcriptomics and bulk RNA-sequencing, we define stromal cell subpopulations and tumor-stromal cross-talk occurring across the histologic and mutational spectrum of thyroid cancer.
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