Matthew Higgs on Muck Rack

Matthew Higgs

  • News Anchor and Reporter, qcountryfm.ca
As seen in: Nature, PLOS, MDPI, Interview Magazine, TV Times, The Paris Review, The Chronicle Herald, What's on TV, JNeurosci, Horse & Hound and
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Articles

Role of Thioredoxin Reductase (TrxB) in Oxidative Stress Response of Francisella tularensis Live Vaccine Strain

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By Matthew Higgs, Zhuo Ma, Anthony J. Centone, Chandra Shekhar Bakshi
| biorxiv.org
Abstract Francisella tularensis is an important human pathogen responsible for causing tularemia in the Northern Hemisphere. Francisella has been developed as a biological weapon in the past due to its extremely high virulence. F. tularensis is a Gram-negative, intracellular pathogen that primarily infects macrophages. To counteract the reactive oxygen and nitrogen species (ROS/RNS) produced by macrophages in response to infection, F. tularensis encodes a repertoire of antioxidant enzymes.
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By Matthew Higgs
| Front Line Genomics Verified
Since its inception, CRISPR has made signification strides towards personalised medicine. It currently offers options for tailored treatment based on an individual’s genetic profiling, for novel drug target identification/validation and for precise therapeutic interventions. However, major challenges remain in tool development and tool optimisation.
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Flagellar motility and the mucus environment influence aggregation mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection

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By Matthew Higgs, Matthew Greenwald, Cristian Roca, Jade K. Macdonald
| biorxiv.org
Abstract Pseudomonas aeruginosa frequently causes chronic lung infection in individuals with muco-obstructive airway diseases (MADs). Chronic P. aeruginosa infections are difficult to treat, primarily owing to antibiotic treatment failure, which is often observed in the absence of antimicrobial resistance. In MADs, P. aeruginosa forms biofilm-like aggregates within the luminal mucus.
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