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Matthew Holland on Muck Rack

Matthew Holland

As seen in: Folha de S.Paulo, HuffPost, Nature, Yahoo Canada, Environment and Behavior, Deseret News, Education Week, Inside Higher Ed, Prog, BiggerPockets and
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Articles

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

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By Jayden R Sterling, George Joun, Matthew Graus, Tian Du, Mani Kuchibhotla, Terrance G. Johns, G. Gregory Neely, Karen Tran, Chloe Shard, Guillermo Gomez, Ashwini Patil, Diana Shi Verified, Julie-Aurore Losman, Jennifer Baker, Matthew Holland, Paul Brennan Verified, Mathias François, Andreas Kraemer, Susanne Mueller, Yuchen Feng, Paul Workman, Lenka Munoz, Jacinda R. Holtsmark, Antoine deWeck, Angus J. Saxton, Zhihe Lei
| Nature Verified
Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using comprehensive chemical biology approaches in glioblastoma models, we demonstrate that the efficacy of QC6352 and that of its clinical analog zavondemstat are independent of KDM4 inhibition.
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Puerto Rico

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By Zack Giarrizzo, Matthew Holland, Tangala Williams
| BiggerPockets Verified
Forum Categories All Tampa, FL · Member since 2016 · 65 posts · 12 votes Good morning all, Has anyone ever done business in Puerto Rico? Or working with CRIM to get property information? Most Popular Reply Rental Property Investor · Medellin, Colombia · Member since 2019 · 23 posts · 32 votes 7y See this reply in the discussion Arlington, TX · Member since 2015 · 220 posts · 40 votes 10y for many years. Not a very easy place to do business.
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Bactérias de amostras de gelo de 5.000 anos dão pistas para a luta contra os supermicróbios

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By Matthew Holland
| Folha de S.Paulo Verified
Uma equipe de cientistas romenos perfurou um núcleo de gelo de 25 metros na caverna Scǎrișoara em busca de pistas para o desenvolvimento de novos medicamentos. O gelo de 5.000 anos de idade rendeu amostras de bactérias antigas cuja análise em laboratório revelou algo notável. Essas bactérias, que permaneceram intocadas por milhares de anos, foram capazes de crescer em uma variedade de ambientes hostis.
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