Matthew J Barter
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Activation of a Yap1-mesenchymal-like program in β-cells during diabetes
Keywords pancreatic β-cell Yap1 diabetes epithelial-to-mesenchymal transition mitochondrial dysfunction Snail N-cadherin Vimentin beta-cell failure extracellular matrix Research topic(s) CP: metabolism CP: developmental biology Introduction Endodermally derived pancreatic β cells are essential to maintain glucose homeostasis. However, β cells are heterogeneous.
The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk
Methods Cartilage tissue from the distal end of the developing human femur was supplied by the Medical Research Council (MRC)- and Wellcome Trust-funded Human Developmental Biology Resource (HDBR) at Newcastle University (http://www.hdbr.org, project number 200363), Newcastle upon Tyne. Tissues were obtained with appropriate maternal written consent and approval from the Newcastle and North Tyneside NHS Health Authority Joint Ethics Committee.
Epigenetic mechanisms of osteoarthritis risk in human skeletal development
LM has received speaker and consultancy fees from Illumina. We have no other conflicting interest to declare. SJR is funded by The Royal Society (RGS\R1\231319), the JGW Patterson Foundation, the MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA; MR/P020941/1 and MR/R502182/1), and a Versus Arthritis Career Development Fellowship (22615). DR is funded by NIH K99AR078352.
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