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Maureen Yin

As seen in: Nature, Cell Press
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Articles

Unlocking potential: the role of the electron transport chain in immunometabolism

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By Alessia Zotta, Luke A.J. O’Neill, Maureen Yin
| Cell Press Verified
Highlights Reliance on the electron transport chain (ETC) in mammalian innate immunity is demonstrated by its role in NLRP3 inflammasome activation. Recent studies challenge the conventional link between reactive oxygen species (ROS) and NLRP3, emphasizing that forward electron transfer and mitochondria-generated ATP are required for NLRP3 activation via the phosphocreatine shuttle.
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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production - Nature

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By Alexander Hooftman, Christian G. Peace, Dylan Ryan, Emily Day, Anne F. McGettrick, Hiran A. Prag, Cecilia Johansson, Michael Murphy, Christian Frezza, Maureen Yin, Alfonso Bolado-Carrancio, Alva M. Casey, Norma Frizzell, Alexander Von Kriegsheim
| Nature Verified
Abstract Metabolic rewiring underlies the effector functions of macrophages1,2,3, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate–argininosuccinate shunt is induced following lipopolysaccharide stimulation. The shunt, supported by increased argininosuccinate synthase (ASS1) expression, also leads to increased cytosolic fumarate levels and fumarate-mediated protein succination.
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