Max Arran Beesley on Muck Rack

Max Arran Beesley

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Articles

Functional integration of an autologous engineered esophagus in a large-animal model

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By Natalie Durkin, George Hall, Roberto Lutman, Marianna Scuglia, Theodoros Xenakis, Giulia Patera, Daniele Di Biagio, Koji Yamada, Lucinda Tullie, Dominic Scaglioni, Soichi Shibuya, Kornilia Nikaki, Max Arran Beesley, Tarek M. Saleh, Matías Flores, Dominika Borselle, Valerija Karaluka, J. Ciaran Hutchinson, Sahira Khalaf, Olumide Ogunbiyi, Lei Wu, Xia Huang, Wenhui Song, Stavros P. Loukogeorgakis, Alessandro Filippo Pellegata, Sara Mantero, Giulio Cossu, Vivian Li, Osvaldo Borrelli, Paola Bonfanti, Sergi Castellano, Conor McCann, Simon Eaton, Marco Pellegrini, Paolo De Coppi
| Nature Verified
Abstract Tissue engineering of the esophagus has been limited by stent dependance and poor muscle regeneration. Here we report an integrated strategy to engineer a 2.5-cm esophageal segment by microinjecting autologous pericyte-like myogenic precursors and fibroblasts in a decellularized porcine scaffold to repair circumferential defects in 10-kg minipigs (n = 8), modeling pediatric use.
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Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids - Nature Medicine

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By Giuseppe Cala, Max Arran Beesley, Lucinda Tullie, Francesco Panariello, Brendan Jones, Ian C Simcock, Anna David, Alessandro Olivo, Simon Eaton, Davide Cacchiarelli, Jan Deprest, Giovanni Giobbe
| Nature Verified
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-02807-z, published online 4 March 2024.
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Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids - Nature Medicine

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By Giuseppe Cala, Max Arran Beesley, Lucinda Tullie, Francesco Panariello, Brendan Jones, Ian C Simcock, Anna David, Alessandro Olivo, Simon Eaton, Davide Cacchiarelli, Jan Deprest, Giovanni Giobbe
| Nature Verified
Abstract Isolation of tissue-specific fetal stem cells and derivation of primary organoids is limited to samples obtained from termination of pregnancies, hampering prenatal investigation of fetal development and congenital diseases. Therefore, new patient-specific in vitro models are needed. To this aim, isolation and expansion of fetal stem cells during pregnancy, without the need for tissue samples or reprogramming, would be advantageous.
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