1 Introduction Streptococcus pneumoniae (Sp) is a Gram-positive bacterial colonizer of the nasopharynx that can disseminate to cause severe disease (Narciso et al. 2024). These infections are most prevalent in age extremes, with people above 65 having higher incidence and mortality (Centers for Disease Control and Prevention 2022). As the number of older adults is projected to grow in the next 35 years from ~56 to 95 million (Vespa et al.