McKayla E Marrin

Get full text access Log in, subscribe or purchase for full access. References 1. Furness, J.B. The enteric nervous system and neurogastroenterology Nat. Rev. Gastroenterol. Hepatol. 2012; 9:286-294 2. Furness, J.B. Types of neurons in the enteric nervous system J. Auton. Nerv. Syst. 2000; 81:87-96 3. Furness, J.B. The Enteric Nervous System Blackwell Publishing, 2006 4. Furness, J.B. ∙ Costa, M. Types of nerves in the enteric nervous system Neuroscience. 1980; 5:1-20 5.

Abstract The function of the intestine is regulated by direct innervation from a combination of enteric, sensory, and autonomic neurons. A central question in neurobiology is how these distinct peripheral neuron populations collectively control intestinal function. However, disambiguating the functions of intestine-innervating neuronal populations has been a challenge.

Abstract Unrepaired DNA damage encountered by the cellular replication machinery can stall DNA replication, ultimately leading to cell death. In the DNA damage tolerance pathway translesion synthesis (TLS), replication stalling is alleviated by the recruitment of specialized polymerases to synthesize short stretches of DNA near a lesion. Although TLS promotes cell survival, most TLS polymerases are low fidelity and must be tightly regulated to avoid harmful mutagenesis.