McKenna D. Romac

Keywords rhesus macaque transgene blood luciferase gene expression Cre-recombinase AAV amygdala striatum chemogenetics Introduction The lack of a simple, inexpensive, and noninvasive method for repeated monitoring and quantification of in vivo transgene expression in the nonhuman primate (NHP) brain over long periods is a barrier to the use of molecular neuroscience tools in NHPs. While repeated in vivo neuroimaging of transgene expression using positron-emission tomography (PET)1,2,3,4 and...

Abstract The amygdaloid complex mediates learning, memory, and emotions. Understanding cellular and anatomical features specialized in the primate amygdala versus other mammals requires a systematic, anatomically resolved molecular analysis of neuron types. We analyzed five nuclear subdivisions of the primate amygdala with single-nucleus RNA sequencing in macaques, baboons, and humans to examine gene expression profiles for excitatory and inhibitory neurons.