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Jason McCormick on Muck Rack

Jason McCormick

California
As seen in: Medium, Nature, CBS News, The Globe and Mail, Albany Business Review, Charlotte Business Journal, Dallas Business Journal, Orlando Business Journal, Portland Business Journal, Puget Sound Business Journal and
marketing director @DrKilligans tutor @stepuptutoringg
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Articles

GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis

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By Anastasia Oktarina, YingZhen Niu, Andrew Thomson Verified, Nicolas Suhardi, Jason McCormick, Ugur M. Ayturk, Matthew Greenblatt, Lionel B. Ivashkiv, Mathias Bostrom, Xu Yang, Vincentius Jeremy Suhardi
| Nature Verified
Abstract Globally, approximately 1.3 million total joint implants are placed annually, and around 80,000 patients develop aseptic loosening, a leading cause of implant failure driven by peri-implant fibrosis. Here, we show that the BMP-antagonist Gremlin-1 (GREM1), expressed by leptin receptor–expressing skeletal (LEPR⁺) cells, is a key regulator of this process. GREM1 is highly expressed by LEPR⁺ cells in peri-implant fibrotic tissue in mice and humans.
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What Investors Need to Know

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By Jason McCormick
| elblog.pl
Pathway Financial Advisers LLC has modestly increased its stake in JPMorgan Chase, now holding 32,579 shares valued at about $7.8 million. Major investors like Fisher Asset Management and Healthcare of Ontario Pension Plan Trust Fund significantly boosted their holdings, emphasizing confidence in JPMorgan. Insiders, such as General Counsel Stacey Friedman, are strategically reducing their shares, reflecting a nuanced view on the stock’s future.
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Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor - Nature Biomedical Engineering

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By Anastasia Oktarina, Mohammed Hammad, Jason McCormick
| Nature Verified
Abstract The cellular and molecular mediators of peri-implant fibrosis—a most common reason for implant failure and for surgical revision after the replacement of a prosthetic joint—remain unclear. Here we show that peri-implant fibrotic tissue in mice and humans is largely composed of a specific population of skeletal cells expressing the leptin receptor (LEPR) and that these cells are necessary and sufficient to generate and maintain peri-implant fibrotic tissue.
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