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Mea M. Holm on Muck Rack

Mea M. Holm

As seen in: SAGE Publishing, Cell Press
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Articles

Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability

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By Ruslan Rust, Mea M. Holm, Oliver Weinmann, Matteo Egger
| SAGE Publishing
Introduction Nogo-A is a membrane protein enriched in oligodendrocytes, CNS myelin and subtypes of neurons that exerts repulsive and inhibitory effects on growing neurites and vascular tip cells during development, and is an important restricting factor for structural and synaptic plasticity and axonal as well as vascular regeneration after CNS injuries.1–4 With two long hydrophobic sequences at its C-terminus, Nogo-A was primarily seen as a contact-dependent ligand interacting with...
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Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

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By Mea M. Holm, Julia Kaiser Verified, Martin E. Schwab
| Cell Press Verified
Highlights Extracellular vesicles (EVs) carry bioactive proteins and nucleic acids that influence the behavior of target cells in multiple ways. EVs shuttle molecules between neurons and glia with apparent functional consequences on synaptic activity, morphological plasticity, and neurovascular integrity. EVs act as bidirectional vehicles in brain-periphery communication, particularly in the context of neuroinflammation and aging.
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