Yinzhao Wang

Introduction Hadal zones, representing ocean regions with water depth exceeding 6 km below sea level (b.s.l.), constitute the deepest places of Earth’s solid surface.1,2,3 Despite covering less than 1% of the global ocean area, hadal zones encompass 45% of the ocean’s total depth range and consist primarily of 37 hadal trenches located at convergent tectonic plate boundaries, extending down to 11 km b.s.l. at the Challenger Deep in the Mariana Trench.1,2,3 These trenches were formed through...

Abstract Prostate cancer (PCa) progression to treatment-related neuroendocrine PCa (t-NEPC) often involves an early neuroendocrine differentiation (NED) phase lacking identified biomarkers. We utilized GeoMx Digital Spatial Profiling and single-cell RNA sequencing on human PCa tissues ranging from hormone-naïve (HNPC) to t-NEPC, with extensive multi-omics validation. Our results established early NED as a distinct, prognostically adverse subtype.