Baoying Liao

PCOS Polycystic ovary syndrome CON Control STAT3 Signal transducer and activator of transcription 3 IL-22 Interleukin 22 IGFBP5 Insulin-like growth factor binding protein 5 DHEA Dehydroepiandrosterone DHT Dihydrotestosterone CK7 Cytokeratin-7 E-cad E-cadherin DEGs Differential expressed genes KEGG analysis Kyoto Encyclopedia of Genes and Genomes analysis GSEA Gene set enrichment analysis ERα Estrogen receptor α PR Progesterone receptor PAEP Progestagen associated endometrial protein SPP1...

Encapsulate Bryostatin-1 by targeted exosomes enhances remyelination and neuroprotection effects of cuprizone induced demyelinating animal model of multiple sclerosis Xiao-Yu Wu, Baoying Liao, Dan Xiao, Wen-Cheng Wu, Yun Xiao, Tyler Alexander, Sheng-Jiao Song Song, Zhuo-Hua Zhao, Yuan Zhang, Zhen-Hai Wang, Li-Bin Wang and Xing Li Abstract Demyelinating disease is a critical neurological disease, and there is still a lack of effective treatment methods.

Polycystic ovary syndrome (PCOS) is a complex syndrome involving both endocrine and metabolic disorders. Gut microbiota and the intestinal immune factor IL-22 play an important role in the pathogenesis of PCOS. However, the therapeutic role of IL-22 in high androgen-induced PCOS mice is not clear. We aimed to determine the therapeutic effects of IL-22 on the DHEA-induced PCOS mouse model and to explore the possible mechanism of IL-22 in regulating hyperandrogenism-associated PCOS.