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Articles

Characterization of immune cell populations in the tumor microenvironment of colorectal cancer using high definition spatial profiling

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By Juan P. Romero, Stephen Williams, Michelli F. Oliveira, Meii Chung
| biorxiv.org
Abstract Colorectal cancer (CRC) is the second-deadliest cancer in the world, yet a deeper understanding of spatial patterns of gene expression in the tumor microenvironment (TME) remains elusive. Here, we introduce the Visium HD platform (10x Genomics) and use it to investigate human CRC and normal adjacent mucosal tissues from formalin fixed paraffin embedded (FFPE) samples.
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