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Meiou Dai

As seen in: Nature, Molecular Cancer
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Articles

Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer - Molecular Cancer

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By Sophie Poulet, Meiou Dai, Ni Wang, Julien Boudreault, Huong Nguyen, Suhad Ali, Jean-Jacques Lebrun, Girija Daliah, Alan Guillevin, Soaad Galal
| Molecular Cancer Verified
This study used a genome-wide CRISPR/Cas9 loss-of-function screen to reveal markers of sensitivity and resistance to palbociclib in a CDK4/6 inhibitor-sensitive TNBC model. SUM159PT TNBC cells were infected with a genome-wide CRISPR library and transplanted into NSG mice. Palbociclib was administered to mice as tumors grew, and tumors were extracted and sequenced. Biological and technical replicates were measured.
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Differential Regulation of Cancer Progression by CDK4/6 Plays a Central Role in DNA Replication and Repair Pathways

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By Meiou Dai, Julien Boudreault, Ni Wang, Sophie Poulet
| cancerres.aacrjournals.org
Molecular Cell Biology Meiou Dai, Julien Boudreault, Ni Wang, Sophie Poulet, Girija Daliah, Gang Yan, Alaa Moamer, Sergio A. Burgos, Siham Sabri, Suhad Ali and Jean-Jacques Lebrun DOI: 10.1158/0008-5472.CAN-20-2121 Published March 2021 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
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Differential regulation of cancer progression by CDK4/6 plays a central role in DNA replication and repair pathways

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By Meiou Dai, Ni Wang, Julien Boudreault, Sophie Poulet
| cancerres.aacrjournals.org
Research Article Meiou Dai, Julien Boudreault, Ni Wang, Sophie Poulet, Girija Daliah, Gang Yan, Alaa Moamer, Sergio A. Burgos, Siham Sabri, Suhad Ali and Jean-Jacques Lebrun DOI: 10.1158/0008-5472.CAN-20-2121 Abstract Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive.
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