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Soaad Galal on Muck Rack

Soaad Galal

As seen in: Molecular Cancer
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Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer - Molecular Cancer

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By Sophie Poulet, Meiou Dai, Ni Wang, Julien Boudreault, Huong Nguyen, Suhad Ali, Jean-Jacques Lebrun, Girija Daliah, Alan Guillevin, Soaad Galal
| Molecular Cancer Verified
This study used a genome-wide CRISPR/Cas9 loss-of-function screen to reveal markers of sensitivity and resistance to palbociclib in a CDK4/6 inhibitor-sensitive TNBC model. SUM159PT TNBC cells were infected with a genome-wide CRISPR library and transplanted into NSG mice. Palbociclib was administered to mice as tumors grew, and tumors were extracted and sequenced. Biological and technical replicates were measured.
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