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Meiying Chen

As seen in: Nature, Wiley Online Library, MDPI, Royal Society of Chemistry
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Articles

Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1)

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By Jian Yin, Sensen Zhang, Chang Liu, Min Xie, Yuanzhu Gao, Maofei Chen, Yixue Wang, Meiying Chen, Hongxuan Fan, Zi Yang, Huan Li, Boda Zhou, Xudong Chen, Maojun Yang
| Nature Verified
Abstract The proton-coupled amino-acid transporter SLC36A1 (hPAT1) is an atypical H⁺-driven carrier and mediates the intestinal absorption of a wide array of zwitterionic amino-acid analogs, including many compounds with central nervous-system (CNS) activity, as well as the activation of the mTORC1 pathway and the export of amino acids from lysosomes, thereby maintaining cellular amino-acid homeostasis.
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Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain

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By Yingying Su, Jie Deng, Meiying Chen, Kaibin Wu, Peiwen Tang, Chen Wang, Deyi Kong, Ting Xu, Feixue Liang, Wenjun Xin, Yan Wu, Xia Feng, Haiting Fan, Zhengkai Liang
| Nature Verified
Abstract Chronic pain and sleep disorders frequently co-occur and exacerbate each other, yet the neural mechanisms underlying this comorbidity remain poorly understood. Here, we found that hyperactivity of GABAergic neurons in the dorsal division of the lateral septum (LSGABA) drives both pain-like behavior and sleep disruption induced by spared nerve injury (SNI) in male mice.
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Advancing surgical education: An evaluation of laparoscopic simulation training for medical students

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By Wenbin Zhang, Lijun Qu, Yuanyuan Xu, Meiying Chen
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jep14225-sup-0001-Course_Schedule.docx15.5 KB Supporting information. jep14225-sup-0002-Laparoscopic_simulation_training_course_questionnaire.docx21.1 KB Supporting information. jep14225-sup-0003-Spatial_Aptitude_Test.docx703.4 KB Supporting information. REFERENCES 1, , . Surgical training fit for the future: the need for a change. Postgrad Med J. 2022; 98(1165): 820-823. 2, .
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