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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Pan-cancer analysis of tissue-plasma genomic concordance reveals enhanced concordance with liver metastasis and plasma clonality as predictor of poorer overall survival
Abstract Circulating tumor DNA (ctDNA) enables noninvasive tumor genotyping, yet its concordance with tissue remains unclear. Using a 437-gene panel in 1111 pan-cancer patients, we compared somatic variants between ctDNA and matched tissues. ctDNA detection sensitivity (61.5%) correlated with advanced stage (r = 0.955, p = 0.045) and tumor size (r = 0.955, p = 0.045). Actionable alterations were detected in 49.2% (ctDNA) and 77.1% (tissue) of patients.
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