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Microdroplet Chemistry Accelerates aza -Friedel–Crafts Reactions for Three-Component Synthesis of α-Branched Amines Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! α-Branched amines represent a significant class of natural and pharmaceutical molecules with notable biological relevance and medicinal utility. Their efficient construction is commonly achieved through aza-Friedel–Crafts reactions. Traditionally, these transformations require high-boiling solvents, concentrated acids or metal catalysts, high temperatures, and prolonged reaction times.
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