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Mengyin Sha on Muck Rack

Mengyin Sha

As seen in: Cell Press
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Articles

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

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By Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha
| Cell Press Verified
Highlights • Deficiency in apoptotic caspases leads to elevated IFN production by virus infection • Caspase-3 cleaves cGAS, MAVS, and IRF3 to keep apoptosis immunologically silent • Caspase-7 is differently involved in mouse and human cells to cleave cGAS and MAVS • MAVS is cleaved at alternative sites to ensure caspase-mediated negative regulation Summary Viral infection triggers host defenses through pattern-recognition receptor-mediated cytokine production, inflammasome activation, and...
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