Merc Emil Matienzo

Abstract Skeletal muscle frequently encounters hypoxic stress, particularly during exercise, but the specific functions of the hypoxia-inducible factors HIF1α and HIF2α within myofibers remain unclear due to the lack of appropriate in vivo models. Here, we generated 3 complementary mouse models, myofiber-specific triple-PHD knockout (PHD mTKO) and inducible myofiber-specific overexpression of stabilized HIF1α or HIF2α, to delineate isoform-specific roles of HIFα signaling in skeletal muscle.